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Navigate to the location of your iTunes Library.itl file. It is usually found at “C:\Users\username\Music\iTunes”
Right-click the “iTunes Library.itl” file, then choose “Properties“.
Uncheck “Read-only“.
If you have a “Security” tab, select it. Ensure that your account has “Full Control” permissions to the file. If you don’t have this tab, ignore this step.
Click “OK“.
Windows Option 2 – Using Attrib
This option is for expert users who know their way around a Command Prompt. These steps will set the iTunes folder where they are readable again.
Open a Command Prompt by pressing the “Windows Key” + “R“.
Type “CMD” then press “Enter“.
Navigate to the location where the music files are located. For Windows 7 users, it’s normally in the C:\Users\username\Music\iTunes\iTunes Media folder.
Type “attrib *.* -r +a -s -h /s“, then press “Enter“.
This command may take a few minutes to run. Once complete, try to open iTunes again.
Mac OSX Option
Exit iTunes.
From the Finder, press “Command“, “Shift“, and “G“.
Type “~/Music/iTunes/“, then press “Enter“.
In the iTunes folder, there should be a “iTunes Library.itl” file. Rename this file to “iTunes Library.old“.
Open the “Previous iTunes Libraries” folder.
Find a file that says “iTunes Library <date>.itl” where the <date> is the most current date you can find.
Move the “iTunes Library <date>.itl” file to the “~/Music/iTunes/” folder.
Rename the “iTunes Library <date>.itl” file to “iTunes Library.itl“.
Now try to start iTunes.
If none of the above steps work for you, it may be a bit more complex. Some people have told me they just delete the “iTunes Library.itl” file or delete everything in the “C:\Users\username\Music\iTunes” folder except “iTunes Media“, and it works for them. I think it’s risky to do that since you could lose data, but you may want to give that a try if you’re desperate.